Introduction Malaria remains a significant global health burden, particularly in sub-Saharan Africa, where it contributes to high morbidity and mortality. Effective treatment and management rely heavily on early and accurate diagnosis. While microscopy and Rapid Diagnostic Tests (RDTs) are commonly used, the emergence of genetic mutations in malaria parasites has reduced the sensitivity of RDTs. Although recent advances in biomarker research offer promise for improving diagnostics, there is a lack of comprehensive analysis regarding major trends and research directions in this domain. This study aims to address that gap by analyzing published literature on malaria diagnostics through a bibliometric approach. Method Using the Bibliometric R package, a total of 114 articles published between 2011 and 2025 were retrieved from the Scopus database. These articles, drawn from 72 sources, were analyzed to identify major research trends, productive authors, countries, institutions, and collaboration networks. In addition, studies from 2020 to 2025 were systematically reviewed in tabular form, focusing on the work done, methodologies, strengths, and limitations of each study. Results and Discussion The bibliometric analysis revealed a significant increase in publication output from 2015 to 2020. Key topics included diagnosis, with point-of-care testing emerging as a central theme in thematic maps. The most productive countries and authors were identified, alongside notable collaboration networks. However, it was observed that African countries, despite being the most affected by malaria, are underrepresented in terms of research contributions. The systematic review of recent studies highlighted notable advancements in diagnostics, such as the development of novel biomarkers and biosensing technologies. Nonetheless, issues related to clinical validation, manufacturing scalability, and suitability for use in endemic and resource-limited regions remain key challenges. Conclusion This bibliometric and systematic review provides a comprehensive overview of the evolving landscape of malaria diagnostic research. While technological innovations are advancing the field, increased involvement from malaria endemic regions, particularly African countries, is crucial. The findings emphasize the importance of continued investment in accessible, validated diagnostic tools tailored to real-world conditions. This analysis offers valuable insights for researchers, funders, and policymakers to guide future efforts in combating malaria through improved diagnostic strategies Keywords: Biomarkers, Diagnosis, Malaria, Plasmodium species, Rapid Diagnostic Tests
Jumoke Soyemi1, Itunuoluwa Isewon, Babatunde Jesusina, Jenrola Oluwafunmilola, Itunu Babatunmise, Olakunle Omotayo, Jelili Oyelade